Triangular Correlation (TrC) between cancer aggressiveness, cell uptake capability and cell deformability

Brill-Karniely Y.*, Dror D.*, Duanis-Assaf T., Goldstein Y., Schwob O., Millo T., Orehov N., Stern T., Jaber M., Loyfer N. Vosk R., Benyamini H., Bielenberg D., Kaplan T., Buganim Y, Reches M., Benny O.

Science Advances, 2020, Vol. 6, no. 3, eaax2861

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Encapsulated Carbenoxolone Reduces Lung Metastases.

Karsch-Bluman A. , Avraham S., Assayag M., Schwob O. and Benny O. 

Cancers 2019, 11(9), 1383

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Microfluidic Based Fabrication and Characterization of Highly Porous Polymeric Microspheres.

Amoyav B, Benny O.

Polymers. 2019 Mar 5;11(3). pii: E419

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Tissue Necrosis and Its Role in Cancer Progression.

Karsch-Bluman A, Feiglin A, Arbib E, Stern T, Shoval H, Schwob O, Berger M, Benny O.

Oncogene. 2019 Mar;38(11):1920-1935. 

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A robust method for critical micelle concentration determination using coumarin-6 as a fluorescent probe.

Fluksman A, Benny O.

Analytical Methods 2019 v.11 no.30 pp. 3810-3818

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Film and ointment based delivery systems for the transdermal delivery of TNP-470.

Abramov E., Schwob O., Benny O. 

Polymers for Advanced Technologies.June 2019. 30(4)·2586-2595

Amoyav, B. &  Benny, O.

Body on Chip-A Distant Dream or an Emerging Reality?

Drug Des Int Prop Int J 1(4)- 2018. DDIPIJ.MS.ID.000118.

Ella E, Harel Y, Abraham M, Wald H, Benny O, Karsch-Bluman A, Vincent D, Laurent D, Amir G, Izhar U, Shapira OM, Yoon D, Lee HS, Sugarbaker DJ, Burt B, Peled A, Wald O.

Matrix metalloproteinase 12 promotes tumor propagation in the lung.

J Thorac Cardiovasc Surg. 155(5):2164-2175.e1. May 2018

Amoyav, B. & Benny, O.

Controlled and tunable polymer particles’ production using a single microfluidic device.

Appl Nanosci https://doi.org/10.1007/s13204-018-0790-0 April 2018.

Lazarovici P, Lahiani A, Gincberg G, Haham D, Fluksman A, Benny O, Marcinkiewicz C, Lelkes PI.

Nerve Growth Factor-Induced Angiogenesis: 1. Endothelial Cell Tube Formation Assay.

Methods Mol Biol. 1727:239-250. doi: 10.1007/978-1-4939-7571-6_18. 2018

Ehrenberg M, Benny O.

Evolving multidimensional pharmacological approaches to CNV therapy in AMD.

Curr Eye Res. 2018 Feb;43(2):147-154. doi: 10.1080/02713683.2017.1385088. 2018

Larush L, Kaner I, Fluksman A, Tamsut A, Pawar AA, Lesnovski P, Benny O & Magdassi S.

3D printing of responsive hydrogels for drug-delivery systems

J. 3D Print. Med. 2017 Oct 1(4), 219–229

Shoval H, Karsch-Bluman A, Brill-Karniely Y, Stern T, Zamir G, Hubert A, Benny O.

Tumor cells and their crosstalk with endothelial cells in 3D spheroids.

Sci Rep. 2017 Sep 5;7(1):10428. doi: 10.1038/s41598-017-10699-y.

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Karsch-Bluman A, Amoyav B, Friedman N, Shoval H, Schwob O, Ella E, Wald O, Benny O.

High mobility group box 1 antagonist limits metastatic seeding in the lungs via reduction of cell-cell adhesion.

Oncotarget. 16;8(20):32706-32721. 2017

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Stern T*, Kaner I*, Laser Zer N, Shoval H, Dror D, Manevitch Z, Chai L, Brill-Karniely Y, Benny O.

Rigidity of polymer micelles affects interactions with tumor cells. 

J Control Release. pii: S0168-3659(16)30783-0. 2016

Licht T, Rothe G, Kreisel T, Wolf B, Benny O, Rooney AG, Ffrench-Constant C, Enikolopov G, Keshet E.

VEGF preconditioning leads to stem cell remodeling and attenuates age-related decay of adult hippocampal neurogenesis.

Proc Natl Acad Sci U S A. 113(48):E7828-E7836. 2016

Ehrenberg M, Ehrenberg S, Schwob O, Benny O.

Murine fundus fluorescein angiography: An alternative approach using a handheld camera.

Exp Eye Res.Jul;148:74-8. 2016

Abramov E, Cassiola F, Schwob O, Karsh-Bluman A, Shapero M, Ellis J, Luyindula D, Adini I, D'Amato RJ, Benny O. 

Cellular mechanism of oral absorption of solidified polymer micelles.

Nanomedicine 11(8):1993–2002. 2015

Momic T, Katzehendler J, Benny O, Lahiani A, Cohen G, Noy E, Senderowitz H, Eble JA, Marcinkiewicz C, Lazarovici P. 

Vimocin and vidapin, cyclic KTS peptides, are dual antagonists of α1β1/α2β1 integrins with antiangiogenic activity. 

J Pharmacol Exp Ther 350(3):506–519. 2014 

Birsner AE*, Benny O*, D'Amato RJ.

The corneal micropocket assay: a model of angiogenesis in the mouse eye.

J Vis Expo 16 (90). 2014

Adini I, Ghosh K, Adini A, Chi ZL, Yoshimura T, Benny O, Connor KM, Rogers MS, Bazinet L, Birsner AE, Bielenberg DR, D'Amato RJ. 

Melanocyte-secreted fibromodulin promotes an angiogenic microenvironment.

J Clin Invest 124(1):425-436. 2014

Panigrahy D, Kalish BT, Huang S, Bielenberg DR, Le HD, Yang J, Edin ML, Lee CR, Benny O, Mudge DK, Butterfield CE, Mammoto A, Mammoto T, Inceoglu B, Jenkins RL, Simpson MA, Akino T, Lih FB, Tomer KB, Ingber DE, Hammock BD, Falck JR, Manthati VL, Kaipainen A, D'Amore PA, Puder M, Zeldin DC, Kieran MW.

Epoxyeicosanoids promote organ and tissue regeneration.

Proc Natl Acad Sci USA 110(33):13528-13533. 2013

Yoshimura T*, Benny O*, Bazinet L, D'Amato RJ. 

Suppression of autoimmune retinal inflammation by an antiangiogenic drug.

PLoS One 8(6):e66219. 2013

Adini A, Adini I, Ghosh K, Benny O, Pravda E, Hu R, Luyindula D, D'Amato RJ.

The stem cell marker prominin-1/CD133 interacts with vascular endothelial growth factor and potentiates its action.

Angiogenesis 16(2):405-416. 2013

Becker CM, Beaudry P, Funakoshi T, Benny O, Zaslavsky A, Zurakowski D, Folkman J, D'Amato RJ, Ryeom S.

Circulating endothelial progenitor cells are up-regulated in a mouse model of endometriosis.

Am J Pathol 178(4):1782-1791. 2011

Shulman M, Cohen M, Soto-Gutierrez A, Yagi H, Wang H, Goldwasser J, Lee-Parsons CW, Benny O, Yarmush ML, Nahmias Y. 

Enhancement of naringenin bioavailability by complexation with hydroxypropyl-β-cyclodextrin. 

PLoS One 6(4):e18033. 2011

Benny O, Nakai K, Yoshimura T, Bazinet L, Akula JD, Nakao S, Hafezi-Moghadam A, Panigrahy D, Pakneshan P, D'Amato RJ.

Broad spectrum antiangiogenic treatment for ocular neovascular diseases.

PLoS One 5(9):e12515. 2010

Arai T, Benny O, Joki T, Menon LG, Machluf M, Abe T, Carroll RS, Black PM.

Novel local drug delivery system using thermoreversible gel in combination with polymeric microspheres or liposomes.

Anticancer Res 30(4):1057-1064. 2010

Baruch L, Benny O, Gilert A, Ukobnik M, Ben Itzhak O, Machluf M.

Alginate-PLL cell encapsulation system Co-entrapping PLGA-microspheres for the continuous release of anti-inflammatory drugs.

Biomed Microdevices 11(5):1103-1113. 2009

Benny O, Pakneshan P.

Novel technologies for antiangiogenic drug delivery in the brain.

Cell Adh Migr 3(2):224-229. 2009

Benny O, Menon LG, Ariel G, Goren E, Kim SK, Stewman C, Black PM, Carroll RS, Machluf M.

Local delivery of poly lactic-co-glycolic acid microspheres containing imatinib mesylate inhibits intracranial xenograft glioma growth.

Clin Cancer Res 15(4):1222-1231. 2009

Fainaru O, Adini I, Benny O, Bazinet L, Pravda E, D'Amato R, Folkman J.

Doxycycline induces membrane expression of VE-cadherin on endothelial cells and prevents vascular hyperpermeability.

FASEB J 22(10):3728-3735. 2008

Nakai K, Fainaru O, Bazinet L, Pakneshan P, Benny O, Pravda E, Folkman J, D'Amato RJ.

Dendritic cells augment choroidal neovascularization.

Invest Ophthalmol Vis Sci 49(8):3666-3670. 2008

Benny O, Fainaru O, Adini A, Cassiola F, Bazinet L, Adini I, Pravda E, Nahmias Y, Koirala S, Corfas G, D'Amato RJ, Folkman J.

An orally delivered small-molecule formulation with antiangiogenic and anticancer activity.

Nature Biotechnol 26(7):799-807. 2008 JOURNAL COVER

Hilighted: Nat Biotechnol. 2008 Jul;26(7):769-70. .James D, Rabbany S, Rafii S.

Nakai K, Fainaru O, Bazinet L, Pakneshan P, Benny O, Pravda E, Folkman J, D'Amato RJ. 

Dendritic cells support angiogenesis and promote lesion growth in a murine model of endometriosis.

FASEB J 22(2):522-529. 2008

Benny O, Kim SK, Gvili K, Radzishevsky IS, Mor A, Verduzco L, Menon LG, Black PM, Machluf M, Carroll RS.

In vivo fate and therapeutic efficacy of PF-4/CTF microspheres in an orthotopic human glioblastoma model.

FASEB J 22(2):488-499. 2008

Duvshani-Eshet M, Benny O, Morgenstern A, Machluf M.

Therapeutic ultrasound facilitates antiangiogenic gene delivery and inhibits prostate tumor growth.

Mol Cancer Ther 6(8):2371-2382. 2007

Gvili K, Benny O, Danino D, Machluf M.

Poly(D,L-lactide-co-glycolide acid) nanoparticles for DNA delivery: waiving preparation complexity and increasing efficiency.

Biopolymers 85(5-6):379-391. 2007

Benny O, Duvshani-Eshet M, Cargioli T, Bello L, Bikfalvi A, Carroll RS, Machluf M.

Continuous delivery of endogenous inhibitors from poly(lactic-co-glycolic acid) polymeric microspheres inhibits glioma tumor growth.

Clin Cancer Res 11(2 Pt 1):768-776. 2005

Seagal J, Edry E, Keren Z, Leider N, Benny O, Machluf M, Melamed D. 

A fail-safe mechanism for negative selection of isotype-switched B cell precursors is regulated by the Fas/FasL pathway.

J Exp Med 198(10):1609-1619. 2003