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Cover Benzi 2023.JPG



Goldstein Y.,  Cohen OY, Wald O, Bavli D,  Kaplan T, Benny O.

Particle uptake in cancer cells can predict malignancy and drug resistance using machine learning

Sci Adv..2024 May 31;10(22):eadj4370

Dong Y,, Zhang J., Wang Y., Zhang Y., Rappaport D., Yang Z., Han M., Liu Y., Fu Z., Zhao X., Tang C, Shi C., Zhang D., Li D., Ni S., Li, A. Cui J., Li T., Sun P., Benny O., Zhang C., Zhao K., Chen C, Jiang X.

Intracavitary Spraying of Nanoregulator-Encased Hydrogel Modulates Cholesterol Metabolism of Glioma-Supportive Macrophage for Postoperative Glioblastoma Immunotherapy

Adv Mater,. Mar;36(13):e2311109. 2024   


Fluksman A., Lafuente  A., Braunstein  R., Steinberg  E., Friedman  N., Yekhin  Z.,  Roca  AC, Nogues J., Hazan  R., Sepulveda B*., Benny O*. 

Modular drug-loaded nanocapsules with metal dome layers as a platform for obtaining synergistic therapeutic biological activities 

ACS Appl Mater Interfaces. 2023 Oct 20.


Amoyav  B. , Bloom AI, Goldstein Y., Miller R., Sharam M., Fluksman A, Benny O. 

Drug-eluting porous embolic microspheres for trans-arterial delivery of dual synergistic anticancer therapy for the treatment of liver cancer 

Adv Healthc Mater. 2023 Jun 14:e2301548.

Steinberg E, Friedman R., Goldstein Y., Friedman N., Beharier O., Demma JA, Zamir G., Hubert A,, Benny O. 

Fully 3D-printed versatile tumor-on-a-chip allows multi-drug screening and correlation with clinical outcomes for personalized medicine

Commun. Biol. 2023 v6, 1157   

Brill-Karniely Y*., Tischenko, K*,. Benny O.

Analyzing force measurements of multi-cellular clusters comprising indeterminate geometries 
Biomech Model Mechanobiol. 2023  doi: 10.1007/s10237-023-01764-9


Friedman N, Weinstein L, Mostinski Y, , Elia J, Cohen S., Steinberg E, Frankenburg S,, Peretz T, Eisenberg G., Lotem L., Benny O.* and Merims S* 

Preventing skin toxicities induced by EGFR inhibitors by topically blocking drug-receptor interactions

Sci Transl Med. 2023 15, eabo0684; 7

Tischenko K, Brill-Karniely Y, Steinberg E, Segev-Yekutiel H, Benny O.

Surface physical cues mediate the uptake of foreign particles by cancer cells. 

APL Bioeng. 2023 Mar 20;7(1):016113. 

Zemmour  C., Zakharova S, Benny O. 

Generating porous metal surfaces as a mean to incorporate thymol-loaded nanoparticles 

Discov Nano. 2023 Jun 20;18(1):89


Blal K, Besser E, Procaccia S, Schwob O, Lerenthal Y, Abu Tair J, Meiri D*, Benny O.*

The effect of cannabis plant extracts on head and neck squamous cell carcinoma and the quest for cannabis-based personalized therapy.
ancers. 2023 Jan 13;15(2):497. doi: 10.3390/cancers15020497.

Fluksman A, Lafuente A, Li Z, Sort L, Piedrafita SL, Esplandiu ML Maria José, Nogues J, Alejandro G. Roca s, Benny O*, Sepulveda B*

Efficient tumor eradication at ultralow drug concentration via externally controlled and boosted metallic iron magnetoplasmonic nanocapsules 

ACS Nano. 2023 Feb 14;17(3):1946-1958 


Dahan T., Nassar S. Yajuk O., Steinberg E., Benny O., Abudi N., Plaschkes I., Benyamini H., Gozal D., Abramovitch R., Gileles-Hillel A.

Chronic intermittent hypoxia during sleep causes browning of interscapular adipose tissue accompanied by local insulin resistance in mice

Int J Mol Sci. 2022, 23, 15462

Brill-Karniely Y,. Schwob O., Benny O.

The aspect ratio effect on the cytotoxicity of inert nanoparticles flips depending on particle thickness, and is one of the reasons for the literature inconsistency.

Nanoscale Adv. 2022, 4, 5257-5269. 2

Steinberg E, Esa R, Schwob O, Stern T, Orehov N, Zamir G, Hubert A, Panigrahy D, Benny O.

Methionine aminopeptidase 2 as a potential target in pancreatic ductal adenocarcinoma.
Am J Transl Res.
2022 Sep 15;14(9):6243-6255. eCollection 2022.

Esa, R., Steinberg, E., Dagan, A., Yekhtin, Z. Tischenko K. Benny O.

Newly synthesized methionine aminopeptidase 2 inhibitor hinders tumor growth

Drug Deliv and Transl Res. 2022,

Friedman N., Merims S., Elia J., Benny O.

Ex-vivo skin permeability tests of nanoparticles for microscopy imaging

Bio-protocol, 2022. 12(7) E:4375


Goldstein Y*., Tishenko K*., Brill-Karniely Y, Benny O.

Enhanced biomechanically-mediated “phagocytosis” in detached tumor tells

Biomedicines, 2021, 9(8), 9472021.

Friedman  N., Dagan  A., Elia  J , Merims  J, Benny O.

Physical properties of gold nanoparticles affect skin penetration via hair follicles

Nanomedicine. 2021 Jun 22;102414.doi: 10.1016/j.nano.2021.102414.

Minkowicz, L.,Dagan, A..,Uvarov, V..Benny, O.

Controlling calcium carbonate particle morphology, size and molecular order using silicate

Materials. 2021,14, 3525.​

Goldstein Y, Spitz S, Turjeman K, Selinger F, Barenholz Y, Ertl P, Benny O*, Bavli D*

Breaking the third wall: implementing 3D-printing techniques to expand the complexity and abilities of multi-organ-on-a-chip devices

Micromachines. 2021 May 12, 627


Amoyav B, Goldstein Y, Steinberg E, Benny O.

3D printed microfluidic devices for drug release assays

Pharmaceutics. 2020 Dec 23;13(1):13.


Rosenberg S., Steinberg E., Yaacov A., Lutati R., Mordechai A., Linetsky E., Lossos A., Paldor I., Benny O.

Spheroids study of a glioblastoma tumor identified a subclonal mutation of EGFR T790M

Neuro-Oncology, 22, Issue Supplement_2, Nov. 2020, Page ii75,

Steinberg  E, Fluksman  A, Zemmour  C, Tischenko  K, Karsch-Bluman  A, Brill-Karniely Y, Birsner A, D'Amato  RJ, Benny O.  

Low dose amiodarone reduces tumor growth and angiogenesis

Sci Rep. 2020 Oct 22;10(1):18034.

Esa R, Steinberg E, Dror D, Schwob O, Khajavi M, Maoz M, Kinarty Y, Inbal A, Zick A, Benny O.

The role of methionine aminopeptidase 2 in lymphangiogenesis
Int J Mol Sci. 2020 Jul 21;21(14):5148. doi: 10.3390/ijms21145148.


Steinberg E*, Orehov N*, Tischenko K, Schwob O, Zamir G, Hubert A, Manevitch Z, Benny O.

Rapid clearing for high resolution 3D imaging of Ex Vivo pancreatic cancer spheroids

Int J Mol Sci. 2020 Oct 18;21(20):E7703


Fluksman A., Steinberg E., Orehov N., Shai E., Lahiani A., Katzhendler J., Marcinkiewicz C., Lazarovici P., Benny O.

Integrin α2β1 targeted self-assembled nanocarriers for tumor bioimaging

ACS Appl Bio Mater. 2020, 3, 9


Brill-Karniely Y.*, Dror D.*, Duanis-Assaf T., Goldstein Y., Schwob O., Millo T., Orehov N., Stern T., Jaber M., Loyfer N. Vosk R., Benyamini H., Bielenberg D., Kaplan T., Buganim Y, Reches M., Benny O.

Triangular Correlation (TrC) between cancer aggressiveness, cell uptake capability and cell deformability

Science Advances, 2020, Vol. 6, no. 3, eaax2861.



Fluksman, A, Benny, O.

A robust method for critical micelle concentration determination using coumarin-6 as a fluorescent probe

Anal Methods, 2019,11, 3810-3818 (2.896, 0.615, 24)

Karsch-Bluman A., Avraham S., Assayag M., Schwob O. and Benny O.

Encapsulated carbenoxolone reduces lung metastases

Cancers 2019, 11(9), 1383


Amoyav B, Benny O.

Microfluidic based fabrication and characterization of highly porous polymeric microspheres

Polymers. 2019 Mar 5;11(3). pii: E419


Abramov E., Schwob O, Benny O.

Film‐ and ointment‐based delivery systems for the transdermal delivery of TNP‐470

Polym Adv Technol. 2019 30:10: 2586-2595


Karsch-Bluman A, Feiglin A, Arbib E, Stern T, Shoval H, Schwob O, Berger M, Benny O.

Tissue necrosis and Its role in cancer progression

Oncogene. 2019 Mar;38(11):1920-1935.



Amoyav B., Benny O. 

Controlled and tunable polymer particles’ production using a single microfluidic device
Applied Nanoscience volume 8, pages905–914 (2018)


Ella E, Harel Y, Abraham M, Wald H, Benny O., Karsch-Bluman A, Vincent D, Laurent D, Amir G, Izhar U, Shapira OM, Yoon D, Lee HS, Sugarbaker DJ, Burt B, Peled A, Wald O. 

Matrix metalloproteinase 12 promotes tumor propagation in the lung

J Thorac Cardiovasc Surg. 2018 May;155(5):2164-2175


Lazarovici P., Lahiani A., Gincberg G., Haham D., Fluksman A., Benny O., Marcinkiewicz C., Lelkes PI.

Nerve growth factor-induced angiogenesis: 1. Endothelial cell tube formation assay

Methods Mol Biol. 2018;1727:239-250

Amoyav B. and Benny O.

Body on Chip-A Distant Dream or an Emerging Reality?

Drug Des Int Prop Int J. 2018; 1(4)


Ehrenberg M, Benny O.

Evolving multidimensional pharmacological approaches to CNV therapy in AMD

Curr Eye Res. 2017 Nov 7:1-8.


Shoval H, Karsch-Bluman A, Brill-Karniely Y, Stern T, Zamir G, Hubert A, Benny O. 

Tumor cells and their crosstalk with endothelial cells in 3D spheroids

Sci Rep. 2017 Sep 5;7(1):10428.


Karsch-Bluman A, Amoyav B, Friedman N, Shoval H, Schwob O, Ella E, Wald O, Benny O.

High mobility group box 1 antagonist limits metastatic seeding in the lungs via reduction of cell-cell adhesion

Oncotarget. 2017 May 16;8(20):32706-32721.


Larush L, Kaner I, Fluksman A, Tamsut A, Ashok Pawar A, Lesnovski P, Benny O, Magdassi S.

3D printing of responsive hydrogels for drug-delivery systems. 

J of 3D Printing in Medicine. 2017 Oct; Vol. 1, No. 4,


Stern T, Kaner I, Laser Zer N, Shoval H, Dror D, Manevitch Z, Chai L, Brill-Karniely Y, Benny O.

Rigidity of polymer micelles affects interactions with tumor cells

J Control Release. 2017 Jul 10;257:40-50.


Abramov E, Schwob O, Benny O.

Analytical method for transdermal delivery of the anti-angiogenic compound TNP-470

J Anal Bioanal Tech. 2017 May 24; 8:365.



Licht T, Rothe G, Kreisel T, Wolf B, Benny O, Rooney AG, Ffrench-Constant C, Enikolopov G, Keshet E.

VEGF preconditioning leads to stem cell remodeling and attenuates age-related decay of adult hippocampal neurogenesis

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7828-E7836.


Ehrenberg M, Ehrenberg S, Schwob O, Benny O.

Murine fundus fluorescein angiography: An alternative approach using a handheld camera.

Exp Eye Res. 2016 Jul;148:74-78.



Abramov E, Cassiola F, Schwob O, Karsh-Bluman A, Shapero M, Ellis J, Luyindula D, Adini I, D'Amato RJ, Benny O.

Cellular mechanism of oral absorption of solidified polymer micelles.

Nanomedicine. 2015 Nov;11(8):1993-2002.


 Birsner AE*, Benny O*, D'Amato RJ.

The corneal micropocket assay: a model of angiogenesis in the mouse eye

J Vis Exp. 2014 Aug 16;(90).


Momic T, Katzehendler J, Benny O, Lahiani A, Cohen G, Noy E, Senderowitz H, Eble JA, Marcinkiewicz C, Lazarovici P.

Vimocin and vidapin, cyclic KTS peptides, are dual antagonists of α1β1/α2β1 integrins with antiangiogenic activity

J Pharmacol Exp Ther. 2014 Sep;350(3):506-19.


Adini I, Ghosh K, Adini A, Chi ZL, Yoshimura T, Benny O, Connor KM, Rogers MS, Bazinet L, Birsner AE, Bielenberg DR, D'Amato RJ.

Melanocyte-secreted fibromodulin promotes an angiogenic microenvironment

J Clin Invest. 2014 Jan;124(1):425-36.



Panigrahy D, Kalish BT, Huang S, Bielenberg DR, Le HD, Yang J, Edin ML, Lee CR, Benny O, Mudge DK, Butterfield CE, Mammoto A, Mammoto T, Inceoglu B, Jenkins RL, Simpson MA, Akino T, Lih FB, Tomer KB, Ingber DE, Hammock BD, Falck JR, Manthati VL, Kaipainen A, D'Amore PA, Puder M, Zeldin DC, Kieran MW.

Epoxyeicosanoids promote organ and tissue regeneration

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13528-33.


Yoshimura T*, Benny O*, Bazinet L, D'Amato RJ.

Suppression of autoimmune retinal inflammation by an antiangiogenic drug

PLoS One. 2013 Jun 13;8(6):e66219.


Adini A, Adini I, Ghosh K, Benny O, Pravda E, Hu R, Luyindula D, D'Amato RJ.

The stem cell marker prominin-1/CD133 interacts with vascular endothelial growth factor and potentiates its action

Angiogenesis. 2013 Apr;16(2):405-16.



Panigrahy D, Edin ML, Lee CR, Huang S, Bielenberg DR, Butterfield CE, Barnés CM, Mammoto A, Mammoto T, Luria A, Benny O, Chaponis DM, Dudley AC, Greene ER, Vergilio JA, Pietramaggiori G, Scherer-Pietramaggiori SS, Short SM, Seth M, Lih FB, Tomer KB, Yang J, Schwendener RA, Hammock BD, Falck JR, Manthati VL, Ingber DE, Kaipainen A, D'Amore PA, Kieran MW, Zeldin DC.

Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice

J Clin Invest. 2012 Jan;122(1):178-91.


Shulman M1, Cohen M, Soto-Gutierrez A, Yagi H, Wang H, Goldwasser J, Lee-Parsons CW, Benny O, Yarmush ML, Nahmias Y.

Enhancement of naringenin bioavailability by complexation with hydroxypropyl-β-cyclodextrin

PLoS One. 2011 Apr 6;6(4):e18033.



Becker CM, Beaudry P, Funakoshi T, Benny O, Zaslavsky A, Zurakowski D, Folkman J, D'Amato RJ, Ryeom S.

Circulating endothelial progenitor cells are up-regulated in a mouse model of endometriosis

Am J Pathol. 2011 Apr;178(4):1782-91.



Benny O., Nakai K, Yoshimura T, Bazinet L, Akula JD, Nakao S, Hafezi-Moghadam A, Panigrahy D, Pakneshan P, D'Amato RJ.

Broad spectrum antiangiogenic treatment for ocular neovascular diseases

PLoS One. 2010 Sep 1;5(9). pii: e12515.


Arai T, Benny O, Joki T, Menon LG, Machluf M, Abe T, Carroll RS, Black PM.

Novel local drug delivery system using thermoreversible gel in combination with polymeric microspheres or liposomes

Anticancer Res. 2010 Apr;30(4):1057-64.


Baruch L, Benny O, Gilert A, Ukobnik M, Ben Itzhak O, Machluf M.

Alginate-PLL cell encapsulation system Co-entrapping PLGA-microspheres for the continuous release of anti-inflammatory drugs

Biomed Microdevices. 2009 Oct;11(5):1103-13.


Benny O, Pakneshan P.

Novel technologies for antiangiogenic drug delivery in the brain

Cell Adh Migr. 2009 Apr-Jun;3(2):224-9. Epub 2009 Apr 6.


Benny O, Menon LG, Ariel G, Goren E, Kim SK, Stewman C, Black PM, Carroll RS, Machluf M.

Local delivery of poly lactic-co-glycolic acid microspheres containing imatinib mesylate inhibits intracranial xenograft glioma growth

Clin Cancer Res. 2009 Feb 15;15(4):1222-31.



Fainaru O, Adini I, Benny O, Bazinet L, Pravda E, D'Amato R, Folkman J.

Doxycycline induces membrane expression of VE-cadherin on endothelial cells and prevents vascular hyperpermeability

FASEB J. 2008 Oct;22(10):3728-35.


Benny O, Fainaru O, Adini A, Cassiola F, Bazinet L, Adini I, Pravda E, Nahmias Y, Koirala S, Corfas G, D'Amato RJ, Folkman J.

An orally delivered small-molecule formulation with antiangiogenic and anticancer activity

Nat Biotechnol. 2008 Jul;26(7):799-807. (Journal Cover).


Nakai K, Fainaru O, Bazinet L, Pakneshan P, Benny O, Pravda E, Folkman J, D'Amato RJ.

Dendritic cells augment choroidal neovascularization

Invest Ophthalmol Vis Sci. 2008 Aug;49(8):3666-70.


Benny O, Kim SK, Gvili K, Radzishevsky IS, Mor A, Verduzco L, Menon LG, Black PM, Machluf M, Carroll RS.

In vivo fate and therapeutic efficacy of PF-4/CTF microspheres in an orthotopic human glioblastoma model

FASEB J. 2008 Feb;22(2):488-99.


Fainaru O, Adini A, Benny O, Adini I, Short S, Bazinet L, Nakai K, Pravda E, Hornstein MD, D'Amato RJ, Folkman J.

Dendritic cells support angiogenesis and promote lesion growth in a murine model of endometriosis

FASEB J. 2008 Feb;22(2):522-9.



Duvshani-Eshet M, Benny O, Morgenstern A, Machluf M.

Therapeutic ultrasound facilitates antiangiogenic gene delivery and inhibits prostate tumor growth

Mol Cancer Ther. 2007 Aug;6(8):2371-82.


Gvili K, Benny O, Danino D, Machluf M.

Poly(D,L-lactide-co-glycolide acid) nanoparticles for DNA delivery: waiving preparation complexity and increasing efficiency

Biopolymers. 2007 Apr 5-15;85(5-6):379-91.



Benny O, Duvshani-Eshet M, Cargioli T, Bello L, Bikfalvi A, Carroll RS, Machluf M.

Continuous delivery of endogenous inhibitors from poly(lactic-co-glycolic acid) polymeric microspheres inhibits glioma tumor growth

Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):768-76.



Seagal J, Edry E, Keren Z, Leider N, Benny O, Machluf M, Melamed D.

A fail-safe mechanism for negative selection of isotype-switched B cell precursors is regulated by the Fas/FasL pathway

J Exp Med. 2003 Nov 17;198(10):1609-19.

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